Articles by Adiantku

Unfortunately, the COVID-19 pandemic continues to wreak havoc in our daily lives. Regardless of who you are, your life has been impacted in some way. Stress is mounting, and you may need to find a way to decompress while social distancing. Enter stage left my favorite pastime: exercise!

All right, I know what you are thinking: She’s one of those exercise fanatics who is going to tell me that I need to exercise several hours every day. Well, no. What I am going to tell you is that you can make exercise work for you. It is imperative to find your “soulmate workout” or simple activities you can do. You might think that you need to be a certain size or already in shape to engage in exercise. This is simply not true, nor is it helpful for your health and well-being, since exercise — even small amounts — helps … Read the rest

If we only paid attention to ads, it might seem as though alcohol — a beer or glass of wine, a shot of fiery liquor or sophisticated cocktail — merely served as a way to bring people together and make them happy. Drink responsibly, the ads wink, without ever explaining the toll that frequent or excessive alcohol use exacts, particularly at certain stages in life. Because alcohol doesn’t just get us drunk, impair our judgment, and hurt our liver: it can have many other bad effects on our bodies — including effects on the brain.

In a recent editorial in The BMJ, a trio of scientists pointed out that there are three periods in life when the brain goes through major changes and is particularly vulnerable to the effects of alcohol. Two of those periods are at the beginning and end of life. When pregnant women drink alcohol, it … Read the rest

In 2020, the terrible toll of the COVID-19 pandemic largely overshadowed the affliction that remains the leading cause of death in this country: heart disease. In the United States last year, at least twice as many people died from cardiovascular causes as those who died from complications from SARS-CoV-2, the novel coronavirus.

While the challenges from the virus are new, experts have been studying heart disease for decades — and everyone can benefit from that knowledge. “The lifestyle habits that keep your heart healthy may also leave you less vulnerable to serious complications from infections such as COVID-19 and influenza,” says cardiologist Dr. Deepak L. Bhatt, professor of medicine at Harvard Medical School and editor in chief of the Harvard Heart Letter.

So what exactly are those heart-healthy habits? The American Heart Association refers to them as “Life’s Simple 7.” Put simply, they are:

1) Stop smoking

2) Eat … Read the rest

Colorectal cancer (CRC) is the second leading cause of cancer death in the United States. There is compelling evidence that screening to detect CRC early to find and remove precancerous polyps can reduce CRC mortality. However, screening has associated harms, including procedural complications, and inherent limitations. For example, colonoscopy, the most common screening tool in the US, is less effective in preventing cancers of the right, or ascending side, of the colon compared with cancers of the left, or descending, side of the colon.

Moreover, only 60% of US adults recommended for screening actually follow through. Even under the best circumstances, screening is resource-intensive, requiring time, equipment, and a trained doctor to perform the procedure, and cannot be widely implemented in many parts of the world. Thus, alternatives to screening to effectively prevent CRC are a high unmet need.

What are alternatives to screening for prevention of colorectal cancer?

Adherence … Read the rest

Products containing cannabidiol (CBD) seem to be all the rage these days, promising relief from a wide range of maladies, from insomnia and hot flashes to chronic pain and seizures. Some of these claims have merit to them, while some of them are just hype. But it won’t hurt to try, right? Well, not so fast. CBD is a biologically active compound, and as such, it may also have unintended consequences. These include known side effects of CBD, but also unintended interactions with supplements, herbal products, and over-the-counter (OTC) and prescription medications.

Doubling up on side effects

While generally considered safe, CBD may cause drowsiness, lightheadedness, nausea, diarrhea, dry mouth, and, in rare instances, damage to the liver. Taking CBD with other medications that have similar side effects may increase the risk of unwanted symptoms or toxicity. In other words, taking CBD at the same time with OTC … Read the rest

Early in the pandemic, epidemiologists made a striking observation. Compared to the general population, people with cardiovascular disease (CVD) were more than twice as likely to contract severe forms of COVID-19. In the last six months, death rates from COVID-19 have dropped significantly, but CVD remains a major predictor of poor outcome. What have we learned about heart disease and COVID-19 in that time?

Pre-existing heart conditions and poor metabolic health increase risk of severe COVID-19

As I described in a blog post back in April, some health conditions, like diabetes, increase risk of severe COVID-19 by suppressing the immune system; others, like asthma, increase risk by weakening the lungs. However, in the early months of the pandemic it was not entirely clear how CVD increased the risk of severe COVID-19. We now have two explanations.

The first is that pre-existing heart conditions, such as damaged heart muscle or blocked … Read the rest

Falls rank among the top causes of death and injuries among the elderly, and the risk increases significantly in older people being treated for cancer. Now, investigators are reporting that a newer class of drugs for advanced prostate cancer is associated with a significant increase in fall risk.

Called androgen receptor inhibitors, or ARIs, these drugs target testosterone, a hormone that accelerates the growth of prostate tumors. Unlike traditional hormonal treatments that interfere with the body’s ability to make testosterone (known as androgen deprivation therapy, or ADT), ARIs work by preventing testosterone from binding to its receptor on cancer cells. Three ARIs were evaluated in the study — apalutamide, enzalutamide, and darolutamide — and each can limit prostate cancer progression and extend survival. The investigators emphasized that the benefits of using ARIs outweigh the risk of falls and fractures, which are rare even in treated patients.

What the investigators did